Tweetbot

Tweetbot is a full-featured OS X Twitter client with a lot of personality. Whether it's the meticulously-crafted interface, sounds and animation, or features like multiple timelines and column views, there's a lot to love about Tweetbot. Features Multiple Timelines. Quickly switch between your lists as your main timeline. Multiple Windows and Columns. Display timelines from different accounts side by side. Notification Center support. Beautiful Retina graphics. Mute filters lets you block messages from users without unfollowing them. You can also mute hashtags and specific keywords. Sync timeline position, direct message read statuses, and mute filters between your Mac, iPhone, and iPad via iCloud. Support for multiple services like Pocket, Instapaper, Readability, CloudApp, and Droplr. Save drafts, add locations and POI's, attach photos/videos, manage your lists, and much more.